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Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality

机译：全合成杀伤力的全基因组RNA干扰分析确定了DNA损伤反应途径中的基因相互作用

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Here, we describe a systematic search for synthetic gene interactions in a multicellular organism, the nematode Caenorhabditis elegans. We established a high-throughput method to determine synthetic gene interactions by genome-wide RNA interference and identified genes that are required to protect the germ line against DNA double-strand breaks. Besides known DNA-repair proteins such as the C. elegans orthologs of TopBP1, RPA2, and RAD51, eight genes previously unassociated with a double-strand-break response were identified. Knockdown of these genes increased sensitivity to ionizing radiation and camptothecin and resulted in increased chromosomal nondisjunction. All genes have human orthologs that may play a role in human carcinogenesis.

机译：在这里，我们描述了在多细胞生物线虫秀丽隐杆线虫中的合成基因相互作用的系统搜索。我们建立了一种高通量方法，可通过全基因组RNA干扰确定合成基因的相互作用，并鉴定出保护种系免受DNA双链断裂所需的基因。除了已知的DNA修复蛋白（例如TopBP1，RPA2和RAD51的秀丽线虫直系同源物）外，还鉴定了八个以前与双链断裂反应不相关的基因。这些基因的敲除增加了对电离辐射和喜树碱的敏感性，并导致增加了染色体的非分离性。所有基因都有可能在人类致癌作用中起作用的人类直系同源物。

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van Haaften, Gijs; Vastenhouw, Nadine L.; Nollen, Ellen A. A.; Plasterk, Ronald H. A.; Tijsterman, Marcel;
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年度 2004
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1. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. [J] . van Haaften G, Vastenhouw NL, Nollen EA, Proceedings of the National Academy of Sciences of the United States of America . 2004,第35期

机译：DNA损伤反应途径中的基因相互作用通过合成杀伤力的全基因组RNA干扰分析确定。
2. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene [J] . Luo J, Emanuele MJ, Li DN, Cell . 2009,第5期

机译：全基因组的RNAi筛选确定与Ras致癌基因的多个合成致命相互作用。
3. A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo [J] . Sandra Morandell, H.?Christian Reinhardt, Ian?G. Cannell, Cell Reports . 2013,第4期

机译：一种可逆的基因靶向策略确定体内DNA损伤反应中MK2和p53之间的合成致死相互作用。
4. Cluster-based multifactor dimensionality reduction method to identify gene-gene interactions for quantitative traits in genome-wide studies [C] . Yoojung Lee, Hyein Kim, Taesung Park, IEEE International Conference on Bioinformatics and Biomedicine . 2017

机译：基于聚类的多维度降维方法，用于在全基因组研究中鉴定数量特征的基因-基因相互作用
5. Gene-gene interaction and gene-pathway analysis of genome-wide association for schizophrenia. [D] . Nassar, Aaya M. 2012

机译：精神分裂症的全基因组关联的基因-基因相互作用和基因-途径分析。
6. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality [O] . Gijs van Haaften, Nadine L. Vastenhouw, Ellen A. A. Nollen, 2004

机译：全合成杀伤力的全基因组RNA干扰分析确定了DNA损伤反应途径中的基因相互作用
7. Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality [O] . van Haaften, Gijs, Vastenhouw, Nadine L, Nollen, Ellen A A, 2004

机译：全合成杀伤力的全基因组RNA干扰分析确定了DNA损伤反应途径中的基因相互作用

Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality

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